• NEWS . 27 Jan 2020
  • Atherosclerosis gene linked with increased risk of ACS in Chinese Han

  • A gene associated with the pathogenesis of atherosclerosis has been linked with an increased risk of acute coronary syndrome (ACS) in a population of Chinese Han.

    Researchers have long recognized that macrophage migration inhibitory factor (MIF) is a major player in the pathogenesis of atherosclerosis, so they investigated the association between MIF gene polymorphisms and ACS. The genetic polymorphisms of MIF (rs755622, rs1007888 and rs2096525) were analysed in 1,153 healthy controls and 699 ACS cases in a population of Chinese Han living in Xinjiang, the northwest part of China. Plasma MIF level was also randomly measured in some of the healthy controls (129; 11.2%) and ACS patients (139; 19.9%).

    Most participants including healthy controls and ACS patients carried rs755622 GG (63.1% and 56.7%, respectively) and CG genotypes (33.1% and 38.9%) and the G allele of rs755622 (79.6% and 76.1%), whereas CC genotype (3.8% and 4.4%) and C allele (20.4% and 23.9%) carriers were the lowest. Multivariate logistic regression analysis showed that carriers with rs755622 C allele had a higher risk of ACS compared with other genotypes (adjusted odds ratio, 1.278, 95% confidence interval, 1.042–1.567). In addition, CC genotype carriers had the highest plasma levels of MIF than the other genotype carriers.

    Therefore, identification of this MIF gene rs755622 polymorphism may help in predicting the risk of ACS.

    Reference:
    Du GL, et al. MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case-control study. Sci Rep 2020;10:140.