• NEWS . 25 Nov 2019
  • Depression after ACS impacts long-term cardiac outcomes

  • Depression, whether arising early or late, after acute coronary syndrome (ACS) in patients is associated with higher incidence of major adverse cardiac events (MACE) in a 5–12 year follow-up study.

    In the study, researchers from South Korea and the UK evaluated ACS patients for depressive disorder within 2 weeks (early phase) and at 1 year (late phase) of ACS for long-term cardiac outcomes. Between 2007 and 2012, they recruited 757 patients with ACS and evaluated them for depression.

    The principal findings of this 5–12 year follow-up study in patients with recent ACS were that MACE incidence was significantly higher in patients with comorbid depressive disorder at early or late phase of ACS than those without, and the presence of depressive disorder at both early and late phases of ACS was associated with worst outcomes.

    The researchers recommend screening and in-depth evaluation of depression, in the late as well as early phase after ACS. Furthermore, interventions to treat and prevent depression also need further evaluation, since the issue has been raised as to whether treatment of depression could improve cardiac outcomes in patients with ACS and mortality in general populations.

    Kim JM, et al. Impact of depression at early and late phases following acute coronary syndrome on long-term cardiac outcomes. J Affect Disord 2020;260:592-596.