- NEWS . 31 Jan 2020
No association between ACS and telomeres in older patients
Researchers have not found a link between short telomeres or low telomerase activity and poor outcomes in older patients with non-ST elevation acute coronary syndrome (NSTEACS) undergoing invasive management. This is despite NSTEACS occurring more frequently in older patients, with an increased rate of recurrent cardiac events after the index presentation.
Of 298 patients recruited in this study, 153 had peripheral blood mononuclear cells recovered. The mean age was 81.0±4.0 years (64% male). Mean telomere length T/S ratio was 0.47±0.25 and mean telomerase activity was 1.52±0.61 units. The primary clinical outcome, defined as death, myocardial infarction, unplanned revascularization, stroke and significant bleeding recorded at 1 year, occurred in 44 (28.8%) patients.
The findings revealed no association between short telomeres or low telomerase activity and incidence of the primary clinical outcome (hazard ratio [HR], 1.50; 95% confidence interval [CI], 0.68–3.34; p=0.32 and HR, 1.33; 95% CI, 0.52–3.36; p=0.51, respectively).
Chan D, et al. The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome. PLoS One 2020;15:e0227616.