• NEWS . 23 Sep 2019
  • Osteopontin and NT-proBNP are biomarkers associated with circulating miRNA levels in acute coronary syndrome

  • Researchers are getting tantalizingly close to identifying associations of known cardiac-related and novel dense microRNAs (miRNAs) with two prognostic biomarkers, and elucidating potential genomic networks regulating these biomarkers. The latest results, highlighting plausible biological pathways connecting miRNAs with osteopontin (OPN) and N-terminal pro-brain natriuretic peptide (NT-proBNP) and outcomes, may contribute to characterizing genomic pathways underlying non-ST-segment elevation acute coronary syndrome (NSTE-ACS) outcomes.

    Currently, only protein biomarkers report on underlying disease severity and prognosis in NSTE-ACS, so researchers hypothesized that integration of dense microRNA (miRNA) profiling with biomarker measurements would highlight potential regulatory pathways that underlie the relationships between prognostic biomarkers, miRNAs and cardiovascular phenotypes. MicroRNAs are short non-coding RNA molecules which bind to target mRNAs and thus regulate gene expression.

    Using whole blood from 186 patients enrolled in the TRILOGY-ACS trial, researchers performed miRNA sequencing and looked for associations with seven circulating prognostic biomarkers. Ten miRNAs, including known cardiac-related miRNAs 25-3p and 423-3p, were associated with NT-proBNP levels and 48 miRNAs, including cardiac-related miRNAs 378a-3p, 20b-5p, and 320a, -b and -d, were associated with OPN levels. NT-proBNP and OPN were also associated with time to cardiovascular death, myocardial infarction or stroke.

    Kwee LC, et al. Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome. Physiol Genomics 2019 Sep 18. doi: 10.1152/physiolgenomics.00033.2019. [Epub ahead of print]