• NEWS . 06 Jan 2020
  • Researchers find biomarkers for nephropathy risk in ACS patients

  • Patients with acute coronary syndrome (ACS) who develop contrast-induced nephropathy (CIN) have significantly higher mean platelet volume-to-lymphocyte ratio (MPVLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) counts than those who do not develop CIN (p≤0.001).

    Researchers in Turkey retrospectively collected the data of 564 patients with ACS after coronary angiography. They compared 62 (10.9%) patients who developed CIN with the remaining 502 (89%) patients who did not develop CIN.

    The findings show a good association of these indices with the development of CIN in patients with ST-elevation myocardial infarction and non-ST-elevation acute coronary syndrome who underwent percutaneous coronary intervention. NLR, MPVLR and PLR are simple, cheap and easily accessible tests that can predict CIN; and the researchers noted that MPVLR was the strongest of these three predictors.

    Reference:
    Zorlu C, et al. Comparison of the relationship Between inflammatory markers and contrast-induced nephropathy in patients with acute coronary syndrome after coronary angiography. Angiology 2019:3319719892160 [Epub ahead of print].