• NEWS . 02 Dec 2019
  • Schizophrenic patients with ACS have higher risk of death: meta-analysis

  • In patients with schizophrenia, acute coronary syndrome (ACS) was associated with a significantly higher risk of mortality (multivariate adjusted risk ratio [RR], 1.66; p<0.001) compared with the results of mentally healthy patients.

    It is known that patients with schizophrenia have a higher incidence of coronary artery disease; therefore, Chinese researchers performed a meta-analysis to evaluate the influence of a prior diagnosis of schizophrenia on mortality after ACS. The meta-analysis included 3,611,343 hospitalized patients with ACS from nine follow-up studies.

    Furthermore, subgroup analyses revealed that patients with schizophrenia were associated with higher ACS mortality within 1 month (RR, 1.68; p<0.001) and during a follow-up period of ≥1 year (RR, 1.71; p=0.01), in studies with (RR, 1.65; p=0.06) and without (RR, 1.68; p=0.004) the adjustment of revascularization treatments, compared with the results of mentally healthy patients.

    These results should be used to raise awareness that, in the case of acute coronary events, patients with schizophrenia have a higher than expected mortality risk.

    Reference:
    Shao M, et al. Mortality risk following acute coronary syndrome among patients with schizophrenia: A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2020;96:109737.