- NEWS . 14 Feb 2020
Smoking impacts mortality post-PCI
Current smokers undergo percutaneous coronary intervention (PCI) at a younger age and have higher short-term mortality compared with ex-smokers and never smokers, according to results from a retrospective analysis.
The aim of this analysis was to assess the impact of smoking on short (30-day) and intermediate (30-day to 6-month) mortality after PCI for acute coronary syndrome (ACS).
This large observational study of non-selected patients demonstrated that ex-smokers and never smokers were of similar age and significantly older than current smokers at first presentation for PCI. Mean age (± standard deviation) was 57 (±11) years in current smokers compared with 67 (±11) years in ex-smokers and 67 (±12) years in never smokers (p<0.0001). The study cohort consisted of 12,656 patients: never smokers (n=4,288), ex-smokers (n=4,806) and current smokers (n=3,562). PCI was performed for ACS in 84.1% of current smokers, 57% of ex-smokers and 62.9% of never smokers (p<0.0001).
In a logistic regression model, the adjusted odds ratios (95% confidence intervals [CIs]) for 30-day mortality were 1.60 (1.10–2.32) in current smokers and 0.98 (0.70–1.38) in ex-smokers compared with never smokers. In the Cox proportional hazard model, the adjusted hazard ratios (95% CI) for mortality between 30 days and 6 months were 1.03 (0.65–1.65) in current smokers and 1.19 (0.84–1.67) in ex-smokers compared with never smokers.
The study researchers concluded that their findings underscore the public message on the benefits of smoking cessation and the harmful effects of smoking.
Parasuraman S, et al. Smoking status and mortality outcomes following percutaneous coronary intervention. Eur J Prev Cardiol 2020. doi: 10.1177/2047487320902325. [Epub ahead of print]