• NEWS . 14 Feb 2020
  • Smoking impacts mortality post-PCI

  • Current smokers undergo percutaneous coronary intervention (PCI) at a younger age and have higher short-term mortality compared with ex-smokers and never smokers, according to results from a retrospective analysis.

    The aim of this analysis was to assess the impact of smoking on short (30-day) and intermediate (30-day to 6-month) mortality after PCI for acute coronary syndrome (ACS).

    This large observational study of non-selected patients demonstrated that ex-smokers and never smokers were of similar age and significantly older than current smokers at first presentation for PCI. Mean age (± standard deviation) was 57 (±11) years in current smokers compared with 67 (±11) years in ex-smokers and 67 (±12) years in never smokers (p<0.0001). The study cohort consisted of 12,656 patients: never smokers (n=4,288), ex-smokers (n=4,806) and current smokers (n=3,562). PCI was performed for ACS in 84.1% of current smokers, 57% of ex-smokers and 62.9% of never smokers (p<0.0001).

    In a logistic regression model, the adjusted odds ratios (95% confidence intervals [CIs]) for 30-day mortality were 1.60 (1.10–2.32) in current smokers and 0.98 (0.70–1.38) in ex-smokers compared with never smokers. In the Cox proportional hazard model, the adjusted hazard ratios (95% CI) for mortality between 30 days and 6 months were 1.03 (0.65–1.65) in current smokers and 1.19 (0.84–1.67) in ex-smokers compared with never smokers.

    The study researchers concluded that their findings underscore the public message on the benefits of smoking cessation and the harmful effects of smoking.

    Reference:
    Parasuraman S, et al. Smoking status and mortality outcomes following percutaneous coronary intervention. Eur J Prev Cardiol 2020. doi: 10.1177/2047487320902325. [Epub ahead of print]