- NEWS . 04 May 2020
Ethnic differences in the pathobiology of ACS between Asians and Whites
A study was carried out to ascertain the underlying mechanisms of acute coronary syndromes (ACS) between Asians and Whites.
The study population was stratified into ST-elevation myocardial infarction (STEMI) and non-ST-elevation-ACS (NSTE-ACS). Of the 1,225 patients enrolled, 1,019 were Asian (567 STEMI and 452 NSTE-ACS) and 206 were White (71 STEMI and 135 NSTE-ACS).
Asians were found to have a higher prevalence of diabetes and hypertension among STEMI patients, and a higher prevalence of diabetes and renal insufficiency but lower prevalence of hyperlipidaemia in NSTE-ACS patients. A significant difference in incidence of plaque rupture, plaque erosion and calcified plaque was reported between ethnic groups for STEMI patients (p=0.001) but not for NSTE-ACS patients.
The study concluded that after adjusting for clinical confounders, Asian and White patients presenting with STEMI and NSTE-ACS showed similar underlying mechanisms of ACS, with the only difference being a higher risk of calcified plaques in Whites with NSTE-ACS (odds ratio, 2.125; 95% confidence interval, 1.213–3.723; p=0.008).
Russo M, et al. Ethnic differences in the pathobiology of acute coronary syndromes between Asians and Whites. Am J Cardiol 2020. doi: 10.1016/j.amjcard.2020.03.017. [Epub ahead of print]